ARPA-H Opportunities
*Updated 8/30*
ARPA-H Overview
The Advanced Research Projects Agency for Health (ARPA-H) is a research funding agency that supports transformative biomedical and health breakthroughs – ranging from the molecular to the societal – to provide health solutions for all. Below are the current open NIH ARPA-H opportunities and due dates.
If you have not applied to ARPA-H or have questions about the program and/or opportunities (or missed the Proposer's Day), please contact Quyen Wickham (quyen.wickham@asu.edu). Some of these opportunities may be limited submissions.
ARPA-H PRECISE-AI *new
Performance and Reliability Evaluation for Continuous modIfications and uSEability of AI (PRECISE-AI) program aims to develop capabilities that can automatically detect and mitigate AI model degradation. These tools will monitor the performance of clinical AI models, identify if a degradation has occurred, and provide capabilities that can correct for performance degradations without the need for human oversight, thereby reducing the burden on individual operators. Draft solicitation is available now.
- Proposer's Day: October (exact date tba)
ARPA-H POSEIDON
The Platform Optimizing SynBio for Early Intervention and Detection in Oncology (POSEIDON) program intends to develop first-in-class, at-home, synthetic Multi-Cancer-Early Detection (MCED) tests for the most sensitive and specific stage I detection of 30+ solid tumors using only breath and/or urine samples. By driving innovation and expanding access to cancer screening, this ambitious program directly supports the Cancer Moonshot goal to end cancer as we know it.
- Solution Summaries Due Nov 6
ARPA-H GLIDE
The Groundbreaking Lymphatic Interventions and Drug Exploration (GLIDE) program aims to develop physical, pharmacologic, gene, and cell-based therapeutic interventions to treat primary and rare lymphatic disease and chronic conditions complicated by lymphatic dysfunction.
- Due date for Proposer's Day (9/17) Registration: Sept 10
- Solution Summaries Due Oct 31
ARPA-H PRO-MICROBE
Predictions for Real-time Optimization of MICRObiomes of Built Environments (PRO-MICROBE) Exploration Topic to fund research on an indoor environmental quality index to monitor and predict microbial health in buildings, such as homes, hospitals, schools, and offices. Exploration Topics are short-duration, fast-paced efforts with smaller, targeted awards. Each ET will provide foundational proofs-of-concept upon which additional future research will be built.
- Proposal due date: October 4
Mission Office-specific Innovative Solutions Openings (ISO)
The Advanced Research Projects Agency for Health (ARPA-H) is accepting submissions to its Mission Office-specific ISOs:
- Health Science Futures - Accelerating advances across research areas and removing limitations that stymie progress towards solutions for broad ranges of disease and conditions. ISO link on SAM.gov.
- Proactive Health - Creating capabilities to detect and characterize disease risk and promote treatments and behaviors to anticipate threats whether viral, bacterial, chemical, physical, or psychological. ISO link on SAM.gov.
- Resilient Systems - Addressing systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. ISO link on SAM.gov.
- Scalable Solutions - Addressing challenges including geography, distribution, manufacturing, data and information, and economies of scale to develop impactful, timely, and equitable solutions. ISO link on SAM.gov.
Each Mission Office ISO calls for proposals that outline revolutionary—not evolutionary— research and technological advancements. Proposals should investigate unconventional approaches and challenge accepted assumptions to enable leaps forward in science, technology, systems, or related capabilities. Exact award amounts and continued support depend upon projects meeting aggressive research milestones. While the closing date for Solutions Summaries is March 3, 2025, it's advisable to submit as early as possible.