ARPA-H Opportunities
*Updated 1/27*
ARPA-H Overview
The Advanced Research Projects Agency for Health (ARPA-H) is a research funding agency that supports transformative biomedical and health breakthroughs – ranging from the molecular to the societal – to provide health solutions for all. Below are the current open NIH ARPA-H opportunities and due dates. If you have not applied to ARPA-H or have questions about the program and/or opportunities (or missed the Proposer's Day), please contact Quyen Wickham (quyen.wickham@asu.edu). Some of these opportunities may be limited submissions.
RAPID
The Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID) program aims to transform the diagnosis of rare and ultra-rare diseases by developing highly accurate AI-based detection models. RAPID seeks to develop provider-facing tools that prioritize data interoperability and integration into existing clinical workflows, ensuring scalability across health care organizations. RAPID will also design cost effective, direct-to-patient systems that can be remotely deployed to help individuals and their families detect rare diseases at home or in non-clinical settings and route them toward appropriate medical support. To catalyze model development, RAPID aims to integrate data from a fragmented landscape, building the largest curated dataset of longitudinal rare disease patient data that is optimized for training and benchmarking advanced diagnostic algorithms. If successful, RAPID will expand access to rare disease expertise and help patients and health care providers reach an accurate diagnosis in a fraction of the time it takes today.
- Solution Summaries due: Feb 14, 2025
- Full Proposal Due: April 11, 2025
PROSPR
The PROactive Solutions for Prolonging Resilience (PROSPR) program aims to identify biochemical and physiological markers and develop assessment tools that will allow researchers to better understand and target the underlying causes of age-related disease. To achieve this goal, PROSPR will pioneer in-home data collection and clinical trial protocols that can assess age-associated health outcomes in just three years instead of decades of study, accelerating the availability of new therapies. If successful, PROSPR will build a new therapeutic industry with interventions focused on maintaining health during aging.
- Solution Summaries due: Feb 10, 2025
- Full Proposals due: tbd (no later than March 24, 2025)
Mission Office-specific Innovative Solutions Openings (ISO)
The Advanced Research Projects Agency for Health (ARPA-H) is accepting submissions to its Mission Office-specific ISOs:
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Health Science Futures - Accelerating advances across research areas and removing limitations that stymie progress towards solutions for broad ranges of disease and conditions. ISO link on SAM.gov.
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Proactive Health - Creating capabilities to detect and characterize disease risk and promote treatments and behaviors to anticipate threats whether viral, bacterial, chemical, physical, or psychological. ISO link on SAM.gov.
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Resilient Systems - Addressing systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. ISO link on SAM.gov.
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Scalable Solutions - Addressing challenges including geography, distribution, manufacturing, data and information, and economies of scale to develop impactful, timely, and equitable solutions. ISO link on SAM.gov.
Each Mission Office ISO calls for proposals that outline revolutionary—not evolutionary— research and technological advancements. Proposals should investigate unconventional approaches and challenge accepted assumptions to enable leaps forward in science, technology, systems, or related capabilities. Exact award amounts and continued support depend upon projects meeting aggressive research milestones. Solution Summaries are accepted at any time.
Exploration Topics
Exploration Topics (ETs) are fast-paced efforts that pursue topics strategically aligned with ARPA-H Mission Offices. They provide foundational proofs-of-concept to be used in future research. They also allow for a streamlined solicitation and acquisition approach.